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KMID : 0617219980090010003
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Duksung Bulletin Phamaceutical Sciences
1998 Volume.9 No. 1 p.3 ~ p.13
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Synthesis of allylthiopyridazine derivates and hepatoprotective activities
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Abstract
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Allylthio group of the sulfur compounds of garlic oil plays an important role for prevention and treatment of hepatic diseases to be introduced by toxic substances or carbon tetrachloride. Thus allylthio group as a pharmacologically active group was introduced into pyridazine nucleus and a substituent such as halogen or alkoxy was also introduced into the para-posi-tion of allylthio group. Three allylthiopyridazine derivatives were synthesized and their hepatoprotective activities were screened in rat. Under the three compounds (6, 7, 8), 7 and 8 (methoxy-, ethoxy-substituent) are hepatoprotective, but 6 (chloro-substitu-ent) is negative.
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